Laser Ablation Icp Ms Application In Biomedical Research

Laser ablation inductively coupled plasma mass spectrometry la icp ms has been efficiently employed to generate qualitative and quantitative maps of elemental distribution in thin tissue sections of a variety of biological samples for example brain cartilage spinal cord etc.

Laser ablation icp ms application in biomedical research. Laser ablation inductively coupled plasma mass spectrometry la icp ms has received significant attention over the last 10 years and has been widely used for the analysis of biological samples. In the last decad. Application in biomedical research mass spectrometry reviews 2017 36 47 57 alessandra sussulini julia susanne becker and johanna sabine becker abstract. The analysis of essential toxic and therapeutic metals metalloids and nonmetals in biomedical tissues is a key task in the life sciences today and la icp ms has proven to be an excellent complement to the organic ms techniques that are much more commonly employed in the biomedical field.

The present review recent biomedical applications in la icp ms imaging as a stand alone technique and in combination with molecular mass spectrometry imaging techniques are discussed. Applications of la icp ms in the study of neurodegenerative diseases distribution of contrast agents and metallodrugs and. The applications of laser ablation inductively coupled plasma mass spectrometry la icp ms in biomedical research are progressively increasing in the last decade. Laser ablation inductively coupled plasma mass spectrometry la icp ms is proposed for a better understanding of metals and proteins distribution in micrometre structures of human brain tissues.

The technique allows the determination of elements and isotopes in biological tissues and related materials with a spatial resolution typically ranging.